PROJECT: JTC2008: PARKCDNF

Development of an experimental therapeutic strategy using the newly identified growth factor CDNF for treatment of Parkinson?s disease

Abstract

Parkinson?s disease (PD) is a common neurodegenerative disorder of unknown cause resulting in 12-20 new cases per 100.000 people per year in European countries. In the past years several genes have been identified that are implicated in rare familial forms of PD. However, the etiology of more than 95% of PD patients is still unknown. The central symptoms of PD are the consequence of degeneration of nigrostriatal dopaminergic neurons. Promoting survival and antagonizing cell death are therefore the only real targets for the development of a therapeutic concept to cope with idiopathic PD.

Keywords

animal models, behavioural studies, therapy, neurology, Parkinson's disease, neuroanatomy

Call topic

Neurodegeneration

Proposed runtime

2009 - 2012

Project team

Kerstin Krieglstein (Coordinator)
Germany (BMBF)
Mart Saarma
Finland (AKA)
Raimo Tuominen
Finland (AKA)
Eberhard Fuchs
Germany (BMBF)
Olle Lindvall
Sweden (SRC)