Improving Translational Research for Chronic Pain data alignment in preclinical and clinical studies
Abstract
Currently, there is tremendous heterogeneity between protocols in preclinical and clinical chronic pain studies, leading to often incomparable data sets. In addition, clinical and preclinical study design is not well aligned, hampering translation of results from bench to bedside. This relates to patient-reported outcomes in clinical and behavioural assessments in preclinical studies, methodological aspects related to *omic analysis, evoked response analysis via QST, psychosocial data assessments, among others. Furthermore, the relevance of many data are of questionable relevance for patients with chronic pain. Taken together, these facts may explain recent translational failures in chronic pain trials. Within this network, we aim to overcome the large heterogeneity of protocols in preclinical and clinical studies by (i)harmonising protocols (including *omics-approaches) and aligning them in a translational approach. We further aim to (ii)develop recommendations for a minimum and clinically relevant Core Set of Data to be collected, for both, preclinical and clinical trials and (iii)provide a first step towards a joint server infrastructure for a better comparability and analysis of available data resources and future trials. This will improve trial design, avoid research on non-relevant biomarkers and facilitate the translation of research findings into clinical practice with the aim to bring new treatment targets and improve patient stratification for treatment response.
Keywords
*omics, protocol harmonization, data sharing, open science
Call topic
Networking Chronic Pain
Proposed runtime
2023 - 2024
Project team
Esther Pogatzki-Zahn (Coordinator)
Germany (BMBF)
Geert Crombez
Belgium
Kristian Kjaer-Staal Petersen
Denmark
Patricia Lavand'homme
Belgium
Deirdre Ryan
Belgium
Ralf Baron
Germany
Cheryl Stucky
USA
Theodore Price
United States
Didier Bouhassira
France
Jan Vollert
UK
Kirsty Bannister
UK
Eva Kosek
Sweden
Katy Vincent
UK
Luda Diatchenko
Canada
Manuela Schmidt
Austria
Katarzyna Starowicz-Bubak
Poland
Lars Arendt-Nielsen
Denmark
Andrew Sven Cracroft Rice
United Kingdom
Jordi Miro
Spain
Brona Fullen
Ireland
Bruno Pradier
Germany
Daniel Segelcke
Germany