The activity-driven ER-mitochondria Calcium Cycle (ERMCC) and protein misfolding in neurodegenerative diseases: finding targets for therapy
Neurodegenerative diseases like Amyotrophic Lateral sclerosis and Alzheimer?s disease occur mostly without identifyable cause, and are as yet uncurable. The project aims to develop a new strategy of neuroprotection by moderation of the endoplasmic-reticulum-mitochondria-calcium cycle (ERMCC) which links functional and structural metabolism in neurons and plays a central role in neuronal development and survival.
genetics, neurology, Parkinson's disease
2009 - 2012
Thomas Gasser (Coordinator)
United Kingdom (MRC)