PROJECT: JTC2008: ERMCC-NDEG

The activity-driven ER-mitochondria Calcium Cycle (ERMCC) and protein misfolding in neurodegenerative diseases: finding targets for therapy

Abstract

Neurodegenerative diseases like Amyotrophic Lateral sclerosis and Alzheimer?s disease occur mostly without identifyable cause, and are as yet uncurable. The project aims to develop a new strategy of neuroprotection by moderation of the endoplasmic-reticulum-mitochondria-calcium cycle (ERMCC) which links functional and structural metabolism in neurons and plays a central role in neuronal development and survival.

Keywords

animal models, genetics, Alzheimer's Disease, cell biology, neurology, molecular biology, neurophysiology, pharmacology and drug development, structural biology, Amyotrophic Lateral Sclerosis, ER, mitochondria, calcium

Call topic

Neurodegeneration

Proposed runtime

2009 - 2012

Project team

Julian Grosskreutz (Coordinator)
Germany (BMBF)
Bernhard Keller
Germany (BMBF)
Maria Teresa Carri
Italy (MOH)
Javier Garcia-Sancho
Spain (MICINN)