Role of proteases and their inhibitors in pathophysiology and diagnosis of Alzheimer Disease
Abstract
Alzheimer disease (AD) is the most common dementia in the elderly. In vivo
diagnostic procedures are imperfect and there is need for additional biomarkers for
preclinical diagnosis, furthermore no effective therapies are available. Members of
ADtest have identified novel, AD-specific biomarkers in cerebrospinal fluid using
novel proteomics based approaches. Using these data, the ADtest consortium will
address above problems in three areas: (1) validation of new AD biomarkers, (2)
investigation AD pathophysiology (3) investigation of novel therapeutic approaches.
Partners come from clinical, translational and basic science, combining broad
expertise with scientific excellence and bring into ADtest a substantial body of
existing knowledge and data. We will validate newly discovered AD biomarker
profiles and look for novel AD biomarker profiles using a technique coupling high
resolution capillary electrophoresis to mass spectrometry. Members of ADtest have
indentified the proteinase inhibitor testican-1 as an AD biomarker and a potential
disease modulator. This will be further investigated using in vitro and in vivo
approaches. Finally, we will perform structural studies of testican-protease
complexes to discover novel therapeutic targets. Thus, the ADtest consortium will
develop innovative diagnostic technologies, provide novel insights into the
pathophysiology of AD and expose novel therapeutic targets.
Keywords
animal models biological markers neurology molecular biology neuropathology psychiatry structural biology therapy Alzheimer Disease
Call topic
Neurodegeneration
Proposed runtime
2009 - 2012
Project team
Markus Glatzel (Coordinator)
Germany (BMBF)
Holger Jahn
Germany (BMBF)
Isidro Ferrer
Spain (MICINN)
Tim Clausen
Austria (FWF)