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The ERA-Net NEURON has created a data bank comprising information about projects funded by the NEURON partners within their national funding programmes in the area of neuroscience, neurology, and psychiatry. If you wish to search for individual research projects enter search term(s) in one or more fields. In all fields it is possible to use the connectors AND or OR (capitalization not necessary). Within one field, please use only ONE connector. Do not use wildcard characters. Click "search" to run your search and view your projects.
The "Project Search" data bank currently contains 4268 projects with a total funding volume of about 957,265,014 €.Since some funding organisations do not state the funding amount of single projects, the total funding volume is actually much higher.
The following funding organisations are presented:

Austrian Science Fund (FWF), Austria
Academy of Finland (AKA), Finland
Research Foundation – Flanders (FWO), Belgium
Fonds de la Recherche Scientifique (FNRS), Belgium
Canadian Institutes of Health Research – Institute of Neurosciences, Mental Health and Addiction (CIHR-INMHA), Canada
Fonds de recherche du Québec-Santé (FRQS), Québec (Canada)
Centre National de la Recherche Scientifique (CNRS), France
French National Research Agency (ANR), France
Federal Ministry of Education and Research (BMBF), Germany
The Icelandic Centre for Research (RANNIS), Iceland
Chief Scientist Office, Ministry of Health (CSO-MOH), Israel
Ministry of Health (MOH), Italy
Latvian Academy of Sciences (LAS), Latvia
National Science Fund (FNR), Luxemburg
National Centre for Research and Development (NCBR), Poland
Foundation for Science and Technology (FCT), Portugal
Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI), Romania
Slovak Academy of Sciences (SAS), Slovakia
Instituto de Salud Carlos III (ISCIII), Spain
Ministry of Economy and Competitiveness (MINECO), Spain
Swedish Research Council (SRC), Sweden
Medical Research Council (MRC), United Kingdom

Project title:
Cerebral Cavernous Malformations. From pathobiology to therapeutic strategies.

Principal Investigator:
Andreas Fischer

Institutional Address:
Institution: Deutsches Krebsforschungszentrum (DKFZ) - Abt. Vaskuläre Onkologie und Metastasierung (A190)
Department: -
Address: Im Neuenheimer Feld 280
Country: Germany
City: Heidelberg
Postal Code: 69120

Runtime:
Start: 01.04.2012   End: 31.03.2015

Funding volume in €: 293.203

Structure:
Funding institution: BMBF
Part of a Consortium: CCM

Key words:
-

Summary of Project:
Cerebral Cavernous Malformations (CCM) are among the most common vascular malformations of the brain, particularly in young people. Cavernomas can give rise to epileptic seizures and brain hemorhages (stroke). The severity of this disease is related to the lack of success of neurosurgery for lesions located in the brainstem and the spinal cord. Such lesions may lead to death or severe morbidity and novel pharmacological approaches are desperately needed.The genes responsible for familial CCM development have been identified. We know now that these genes are important in the behaviour of endothelial cells lining the brain vessels. However, there are still many unknowns about the function of the CCM genes and consequently about the biology of cavernomas. Our teams have contributed to the understanding of CCM biology. We propose now to decipher the function of CCM proteins and the biology of cavernomas by using an integrated approach, studying all three CCM genes at a time, and combining in vitro approaches and advanced animal models. This way, we intend to assess possible therapeutic strategies in mice that could be implemented in human patients afterwards. Four different European groups will be part of this consortium and collaborate tightly, each putting forward its own expertise.

Additional information:
Cerebral cavernous malformations (CCMs) are vascular lesions mostly located in the central nervous system. Their two main clinical manifestations are epileptic seizures and hemorrhagic stroke, and they are involved in a significant percentage of intracere
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